Over the last several years, we have developed a rat model that mirrors features of seizures and systemic pathology found in temporal lobe epilepsy patients and has permitted us to explore and define the cardiovascular and respiratory consequences of acute and chronic seizures, including the mechanisms for death in epilepsy. Our use of peripheral nerve recordings together with blood pressure, ECG, echocardiography, laryngoscopy, plethysmography, and EEG recordings during seizure activity has enabled us to define peripheral autonomic nerve activity and the extremes of activity that can cause severe brady- or tachyarrhythmias, and central or obstructive apnea.
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